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HIPEC After Surgical Site is Closed Shows Benefits

One of the most popular and effective treatments currently in use for malignant pleural mesothelioma is a procedure known as cytoreductive surgery followed by a rinse of heated chemotherapy. The combination of the two modalities has offered extended survival rate for patients. Following surgical removal of as much of the cancerous tissue as possible, the surgical site is then bathed with the heated solution in hopes that it will kill as many residual cancer cells as possible, thus stopping or slowing the return of the disease. Though effective, the procedure does carry some risks. Now a Greek study has shown that there may be a way to reduce those risks for patients who are considered to be the most frail.

According to a study published in a recent issue of the International Journal of Surgical Oncology, there may be significant benefit to closing the surgical site and then treating the patients with the heated chemotherapy through tubes inserted through the abdominal wall. The report follows a study that followed 105 patients being treated at three different Greek hospitals. The patients were being treated either for mesothelioma or another peritoneal malignancy, and it had been determined that all would benefit from cytoreduction and the heated chemotherapy treatment, which is referred to as HIPEC. The surgery departments used the traditional open abdomen technique on sixty of the patients, but use the closed technique on the remaining 45, then closely examined the outcomes of all of the surgeries. They found that among those who had undergone the open HIPEC procedure, 55% experienced serious complications, with two of the patients dying within days of the procedure having been performed. By contrast, among those who underwent the closed HIPEC procedure only 40% experienced serious complications and there were no resulting deaths from the surgery.

Upon closer analysis of the complications experienced by the patients who’d had the open HIPEC procedure, the surgeons determined that the open procedure presented greater dangers in the areas of blood flow, central venous pressure, pulse rate and systolic blood pressure. Though these may not present a problem for all patients being treated, the researchers concluded that for patients who are more frail, the closed method may be preferable and offer less risk.

Terri Oppenheimer

Terri Oppenheimer is an independent writer, editor and proofreader. She graduated from the College of William and Mary with a degree in English. Her dreams of a writing career were diverted by a need to pay her bills. She spent a few years providing copy for a major retailer, then landed a lucrative career in advertising sales. With college bills for all three of her kids paid, she left corporate America for a return to her original goal of writing. She specializes in providing content for websites and finds tremendous enjoyment in the things she learns while doing her research. Her specific areas of interest include health and fitness, medical research, and the law.

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