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Resveratrol May Increase Impact of Chemotherapy

The scientific journal Food and Chemical Toxicology has published a report indicating that researchers in Korea have discovered new evidence that resveratrol, a natural compound found in red grapes, may be effective in the treatment of malignant pleural mesothelioma.

The study’s author, Yoon-Jin Lee and his scientific team had previously issued a study in 2012 regarding resveratrol in which they revealed that the derivative of the grapes’ skin had retarded the growth of malignant mesothelioma tumors in mice. The phenol had also caused increased cell growth. The study went on for four weeks and involved injecting 20 mg/kg of resveratrol into the laboratory animals.

In the year since that original study, Lee and his colleagues have since discovered that resveratrol may have an equally positive impact on chemotherapy administered on mesothelioma cells.  When resveratrol was combined with clofarabine, a cancer-fighting chemotherapy drug, the tumor suppressing impact of the chemotherapy drug was shown to be stronger. Lee’s study showed that the two together created a greater presence of p53, a tumor-suppressing agent that created more cell death. The team’s hope is that based on their research more studies will be done on the beneficial potential of using resveratrol with chemotherapy.

Resveratrol has been the object of fascination by both the scientific community and the general public for the last several years, and interest increases with the release of each new scientific study pointing to its health benefits. The product is a phenol that is made by extracting materials from the skin of red grapes. It has been found that resveratrol’s impact does not diminish after it has been metabolized by the body, an important point both because it is metabolized quickly and because many other compounds lose their effectiveness. Resveratrol can still be absorbed by cells.

Finding agents and methodologies that assist in the treatment of mesothelioma is an international goal of cancer researchers and oncologists. The researchers involved in the two resveratrol mesothelioma cancer studies are from Korea, a country whose use of asbestos has diminished but was still ongoing through the year 2011, when it began to be regulated. The rate of mesothelioma diagnosis is expected to increase in the coming years, and is not expected to reach its peak until the year 2045.

Terri Oppenheimer

Terri Oppenheimer is an independent writer, editor and proofreader. She graduated from the College of William and Mary with a degree in English. Her dreams of a writing career were diverted by a need to pay her bills. She spent a few years providing copy for a major retailer, then landed a lucrative career in advertising sales. With college bills for all three of her kids paid, she left corporate America for a return to her original goal of writing. She specializes in providing content for websites and finds tremendous enjoyment in the things she learns while doing her research. Her specific areas of interest include health and fitness, medical research, and the law.

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