Malignant mesothelioma is a rare form of cancer. The disease is characterized by tumors that form in the lining of the lungs or the abdomen. Treatment focuses on removing or minimizing the tumors that are identified and preventing their return or spread. New research has provided greater understanding of how cancer cells metastasize, and may help in the development of new therapies.
Molecular Mechanism Within Mesothelioma Cells Tied to Metastasis
It has previously been shown that malignant mesothelioma cells’ development and metastasis are correlated to a transition from the epithelial stage to the mesenchymal stage. Known as EMT, this transition impacts the effect of asbestos fibers that are present in the mesothelium and at the same time increases the disease’s invasiveness.
New research focused on mechanisms within breast cancer cells may yield more information on the dynamic within mesothelioma tumors. The new study was conducted by Robert Weinberg of the Whitehead Institute and Arthur Lambert of AstraZeneca and was published in the journal Developmental Cell. Building on Weinberg’s previous research, which suggested that cancer cells’ metastases is facilitated by being in what is called the quasi-mesenchymal state, the scientists now show that specific molecules within cancer cells enable the formation of new tumors.
Targeting Molecules During Epithelial-Mesenchymal Transition May Control Mesothelioma’s Spread
The research conducted by Weinberg and Lambert may prove helpful to future management of malignant mesothelioma. The pair set out to learn how cancer stem cells remain in the quasi-mesenchymal state that facilitates cancer’s spread. They found that two specific molecules play an important role, and that when they are inactivated the stem cells transition to the far end of the EMT spectrum, minimizing their ability to spread. They also found that the presence of these molecules promoted rapid multiplication of cells.
Speaking of their finding, Weinberg said, “This work gives us some mechanistic understanding of what it is about the quasi-mesenchymal state that drives metastatic tumor growth.” They believe that the new insights will drive the development of therapies to stop metastasis.
If you or someone you love has been diagnosed with malignant mesothelioma, groundbreaking research like this offers real hope. For more information, contact the Patient Advocates at Mesothelioma.net today at 1-800-692-8608.
