Malignant Peritoneal Mesothelioma

What Is Malignant Peritoneal Mesothelioma?

• Peritoneal mesothelioma is a cancer of the peritoneum.[1]
• The peritoneum is a thin membrane that creates the lining of the abdominal cavity, arising from mesothelial cells. It consists of two thin layers called the visceral peritoneum and the parietal peritoneum.[2]
• Mesothelioma is an aggressive type of cancer. In the peritoneum it spreads rapidly from one layer of tissue to the other. It then spreads to other types of tissue and to abdominal organs.[1]
• Known asbestos exposure is present in about half of peritoneal mesothelioma cases.[1]

What Causes This Type of Mesothelioma?

The main cause of any type of mesothelioma is asbestos exposure.[1] The longer and more frequent the exposure, the greater the risk of developing mesothelioma.

Experts believe other risk factors, like genetics and family history, also play a role because not everyone exposed to asbestos develops cancer.[3] Also, some patients with peritoneal mesothelioma have no known history of asbestos exposure.

Prolonged asbestos exposure is most often associated with pleural mesothelioma because exposure is usually through inhalation of the fibers, but it can also trigger the peritoneal form in the abdomen.

There are two possible ways that asbestos fibers may travel to the abdominal cavity and cause peritoneal cancer:[4][5]

• Asbestos fibers may also be ingested and may be present in the sputum. Over time, these fibers reach the peritoneal surface by penetrating the wall of the intestine. This process can ultimately lead to the development of cancerous cells.
• Fibers that have been inhaled may also migrate through the lymphatic system and end up in the abdomen where they cause damage.

How Peritoneal Mesothelioma Develops

Whether they get there through inhalation or ingestion, asbestos fibers in the abdomen become embedded in the cells of the peritoneum. There they trigger inflammation and damage.

Cellular damage can lead to those cells becoming cancerous, growing and dividing out of control. They then develop into tumors that may spread further, through the peritoneum and to other tissues and organs.

What Are the Symptoms of Peritoneal Mesothelioma?

The symptoms of peritoneal mesothelioma may not be obvious, or they may be mild and not show until many years, even decades, after asbestos exposure. Significant and harmful delays in diagnosis often occur for this reason. Peritoneal mesothelioma may cause:[6]

• A feeling of fullness in the abdomen (from fluid accumulation)
• Abdominal pain
• Unintentional and unexplained weight loss
• Diarrhea
• Constipation
• Bowel obstruction
• Anemia
• Fever
• Fatigue
• Nausea
• Vomiting

How Is Peritoneal Mesothelioma Diagnosed?

The early symptoms of peritoneal mesothelioma make it challenging to diagnose. They are similar to symptoms of irritable bowel syndrome, Crohn’s disease, colitis, and other more common gastrointestinal disorders.

Doctors are more likely to diagnose these first, leading to a misdiagnosis. This is especially likely if they are unaware of any asbestos exposure a patient may have experienced.

The first step in getting an accurate diagnosis is a physical exam and a thorough history. Tell your healthcare provider if you have or think you may have experienced asbestos exposure. A physical exam will be followed by these steps in most cases:[7]

• After reviewing your symptoms and performing a physical exam, your doctor may start ordering imaging studies, usually beginning with a simple X-ray or CT scan. These studies can help identify peritoneal changes, such as thickening of the lining, or a tumor mass to suggest the presence of cancer. Other specialized imaging such as MRI or PET/CT scans are usually ordered by specialty providers and may take place after a biopsy.

• A blood test may also be used to determine if you have any tumor markers, any substances that are associated with cancer.

• If there are visible abnormalities on a scan, a biopsy is used to determine a diagnosis. This is usually done by an interventional radiologist, a specialist trained in both reading imaging scans and performing minimally invasive biopsies. Most biopsies can be performed at a local hospital with patients going home the same day.

• In some cases, a more invasive surgical biopsy may be necessary. This happens when the tissue in question is difficult to reach or the routine biopsy could not gather enough cells to give your medical team a firm diagnosis.

At this point, a surgeon will usually recommend a laparoscopy in the operating room under general anesthesia. This allows the surgeon to use a camera to look inside the abdominal cavity looking for any signs of cancer and also choose the best location to biopsy.

Laparoscopy is an excellent instrument by which the surgeon can directly visualize tumors within the abdomen and pelvis and also facilitate a biopsy of a cancerous nodule. However, it has been associated with mesothelioma growing out of the insertion site for the telescope. This is referred to as port site metastases.

In order to avoid this very serious dissemination of mesothelioma to the abdominal wall, laparoscopy for mesothelioma must only be performed through the absolute midline of the abdomen. Usually, the telescopy is placed just above or below the umbilicus. If cancer grows out at a midline port site it can be excised without excessive damage to the muscles, nerves, and fascia that make up the abdominal wall.

How Is Peritoneal Mesothelioma Treated?

Treatment options for peritoneal mesothelioma include the standard therapies of surgery; chemotherapy; radiation is seldom indicated. There are, as well, some new and experimental therapies.

Oncologists, especially those who specifically work with mesothelioma patients, are best suited to plan your treatments. They will most likely recommend a combination of therapies based on your cancer’s stage, your health and age, and your preferences.[8]

Cytoreductive Surgery and HIPEC

A newer, innovative treatment has been used with more success in patients with peritoneal mesothelioma and is now the standard therapy. It is called cytoreductive surgery plus HIPEC, or heated intraperitoneal chemotherapy:[9]

• Cytoreductive surgery. The first step in this procedure is a radical surgery to remove as much cancerous tissue as possible. Completer removal gives the best results.
• Heated chemotherapy. Then heated chemotherapy drugs are administered directly into the abdomen at the end of surgery.
• A potential cure. Only certain patients meet the requirements for this cutting edge treatment, but it has helped many live longer than otherwise expected. Some patients are cured.

Who Are the Leading Peritoneal Mesothelioma Doctors?

Paul Sugarbaker, M.D.

Dr. Paul Sugarbaker is one of the world’s leading experts on peritoneal mesothelioma. He also specializes in treating cancers that have metastasized to the peritoneum. He is the Chief of the Peritoneal Surface Malignancy Program at Washington, D.C.’s Washington Hospital Center. He is also the Director of the Center for Gastrointestinal Malignancies.

During his career, Dr. Sugarbaker has worked both in clinical practice and research, including a decade as a Senior Investigator at the National Cancer Institute. He pioneered a treatment strategy for peritoneal mesothelioma, now known as the Sugarbaker Procedure. It involves using cytoreductive surgery followed by the circulation of heated chemotherapy drugs (HIPEC) throughout the abdominal cavity. The procedure is now used widely and has helped to extend the life expectancy of many peritoneal cancer patients.

Kiran Turaga, M.D.

Dr. Kiran Turaga is a surgical oncologist with a special interest in the treatment of advanced malignancies, including metastatic cancers (cancers that have spread beyond their original site to other parts of the body). Dr. Turaga has published widely on peritoneal mesothelioma.

He is the Professor of Surgical Oncology at the University of Chicago. He recently constructed a working group to provide the multidisciplinary recommendations for the treatment of peritoneal mesothelioma. His guidelines were developed with input from leading experts including surgical oncologists, medical oncologists, pathologists, radiologists, palliative care physicians and pharmacists. His work has increased awareness of this disease and provided appropriate management strategies for malignant peritoneal mesothelioma. 

Dr. Turaga is an expert in regional perfusion including hyperthermic intraperitoneal chemotherapy (HIPEC), a technique that delivers high doses of heated chemotherapy directly to abdominal organs to kill cancer cells that may remain after surgical removal of visible tumors.

He is highly skilled in minimally invasive approaches, including robotic surgery, and uses these innovative techniques to surgically treat and remove life-threatening cancers with smaller incisions and shorter recovery times.

Dr. Turaga is an avid and influential researcher who has published over 100 peer-reviewed articles and is an international authority on peritoneal surface disease. His clinical research focuses on development of novel diagnostics and therapeutics for oligo-metastatic cancer. He is also interested in studying how big data systems can be used to provide the most optimal, cost-effective patient care.

Andrew Blakely, M.D.

Dr. Andrew Blakely is a surgical oncologist specializing in peritoneal surface and retroperitoneal malignancies. A primary focus of his research is to develop novel treatment approaches and modalities to improve pre-operative treatment of peritoneal carcinomatosis.

Currently, Dr. Blakely is a Senior Investigator at the Surgery Branch, National Cancer Institute in Bethesda, Maryland. He is the surgeon designated to work with the multidisciplinary team at the National Institutes of Health on clinical and research studies in malignant peritoneal mesothelioma. Protocols for management of peritoneal mesothelioma are open at the National Institutes of Health and promise to bring new information to bear on this rare disease.

David Bartlett, M.D.

Dr. David Bartlett is currently Professor of Surgery and Director of the Surgical Oncology Program at the Allegheny Medical and Surgical Network. He has extensive experience in the treatment of peritoneal mesothelioma that began two decades ago at the National Institutes of Health.

He has published his data on the management of peritoneal mesothelioma widely in the peer-reviewed literature and is currently engaged in clinical and experimental research with this disease.

Dr. Bartlett served as a Senior Investigator at the Surgery Division of the Center for Cancer Research at the National Cancer Institute, where he developed innovative surgical techniques to treat patients with peritoneal metastases. He is currently President of the Society of Surgical Oncology. 

What Is the Prognosis for Peritoneal Mesothelioma?

The prognosis for peritoneal mesothelioma is generally poor given the aggressive nature of the disease. However, it is usually much better than the outlook for pleural mesothelioma. Overall prognosis improves if you are a candidate for cytoreductive surgery plus HIPEC.[10]

Several factors determine each individual patient’s prognosis:

• Age and health
• Gender
• Stage of the cancer at diagnosis
• Treatments chosen
• Concerning radiological features on CT identified by an experienced radiologist.

For peritoneal mesothelioma, the median survival time without disease progression–that is the time a patient lives from diagnosis with no further worsening of the disease–is just 13.9 months.[10]

How to Improve Prognosis

The best chance you have of a good prognosis for peritoneal mesothelioma is with an early diagnosis. Finding out about it in the early stages gives you more treatment options. Aggressive, early treatments can increase the amount of time patients spend without visible cancer and allow patients to feel good longer.

It is important to discuss the potential risks and complications with your medical care team to ensure you are making the right decision. Choosing a team that has experience with mesothelioma can be very helpful.

The best survival rates are seen with patients who undergo cytoreductive surgery plus HIPEC. A 2017 study involved twenty-nine mesothelioma patients who received surgery followed by heated chemotherapy. Nearly three-quarters of the patients lived longer than five years after treatment, a big improvement in overall survival times.[9]

Getting a diagnosis for peritoneal mesothelioma may be devastating, but you have options and hope. You may get a second opinion and then seek treatment at a Peritoneal Surface Oncology center.

You can choose from among treatments that are aggressive and those that will make you feel more comfortable in the time you have left. You may also be able to file a lawsuit to seek compensation if you were exposed to asbestos in the workplace.

Page Medically Reviewed and Edited by Paul Sugarbaker, M.D.

Dr. Paul Sugarbaker is a leading expert in surgical oncology. He specializes in the surgical treatment of gastrointestinal cancers, peritoneal mesothelioma, and peritoneal metastases. He developed and advanced an important treatment procedure for peritoneal cancers and metastases known as HIPEC. The innovative strategy uses surgery followed by the circulation of heated chemotherapy drugs in the abdomen. Dr. Sugarbaker currently heads up the Peritoneal Surface Malignancy Program and the Center for Gastrointestinal Malignancies at Washington Hospital Center. He also works out of a private practice, Sugarbaker Oncology Associates.

Connect with Mesothelioma Doctor Paul Sugarbaker, M.D.