Welcome to Mesothelioma.net - Turning Hope and Faith into Action.

Well-Differentiated Papillary Mesothelioma

Well-differentiated papillary mesothelioma, or WDPM, is a rare mesothelioma subtype. Mesothelioma is a cancer most often associated with asbestos exposure. However, WDPM may not be related to that risk factor at all. There have been only a couple hundred cases of WDPM ever described or studied, limiting our medical understanding of the disease.

What is known is that WDPM is a subtype of the epithelial variety of mesothelioma, the most common and least aggressive form of this rare cancer. WDPM is usually benign but can turn into malignant mesothelioma. Treatments vary and there is no routine treatment strategy due to the rarity of this condition. It is most often seen in the peritoneum of female patients, although there have been reported pleural and testicular forms of WDPM.

Facts about WDPM

The type of mesothelioma can be identified by its location in the body. Most cases are diagnosed as pleural, meaning they formed in the pleura around the lungs. The next most common form attacks the peritoneum, the lining in the abdomen. Rarely, mesothelioma affects the pericardium around the heart or the tunica vaginalis of the testes. Most cases of WDPM have been peritoneal and in women. There have been reported cases of the other forms as well, although these are even more rare.

Relatively few studies have focused on WDPM. These have examined case studies describing individuals diagnosed with the condition. WDPM is mostly benign and comes with a good prognosis and survival rates. However, it can turn malignant over time. Therefore, anyone diagnosed with WDPM should receive regular screening for malignancies.

Unlike malignant mesotheliomas, WDPM does not typically cause many symptoms. The disease can cause fluid build up in the pleura or peritoneum, which in turn can result in swelling or pain. In the tunica vaginalis it may also cause swelling in the scrotum or lumps on the testicles. There is no standard treatment for WDPM because it is so uncommon.

Papillary Structures

The name of this condition, well-differentiated papillary mesothelioma, is descriptive of its tumor characteristics. Well-differentiated refers to the fact that cells in this kind of tumor resemble healthy cells. Poorly differentiated tumors have cells that are easily distinguished from healthy cells. Well-differentiated tumor cells also grow less rapidly and spread less than those that are poorly differentiated.

The growth pattern of the cells in a WDPM tumor is described as papillary. This means they grow into finger-like structures called papillae. Each structure is lined with a layer of uniform, branching, or coarse mesothelium cells. These structures are only visible under a microscope. To the naked eye, they grow as white to gray nodules between one and three centimeters in diameter. There may be a single tumor or multiple smaller tumors.

Diagnosis of WDPM

WDPM is not alwaysimmediately diagnosed because it does not often present symptoms severe enough to send someone to the doctor. However, if a patient complains of swelling or pain in the abdomen or testes, a doctor will begin with a physical examination. Next, an X-ray, CT scan, or MRI will image the body, allowing a doctor to see any tumors or abnormal tissues.

A biopsy is the next likely step. A thin needle is inserted where the imaging scan shows a potential tumor. The needle removes a small tissue or fluid sample to be examined by a pathologist. In cases where the tumor is unreachable by a biopsy needle, a patient may need to undergo a more invasive procedure to obtain a biopsy sample. Because WDPM does not always present symptoms, the condition is often only diagnosed after a patient has had surgery for another reason and a tumor is discovered.

Pathologists examine biopsy samples under a microscope to determine if the sample is benign or malignant. In addition, the pathologist can collect information to identify the type of cancer and its cellular type. Sometimes characteristic structures of WDPM can be seen in a CT scan. However, the best way to diagnose it is with a biopsy. Since malignant and aggressive types of mesothelioma may have papillary structures, a biopsy to distinguish between these cancers and WDPM is important for informing treatment.

Even with a biopsy, it is possible to misdiagnose WDPM. WDPM may be mistaken for an adenomatoid tumor, tuberculosis peritonitis, different types of papillary carcinomas, peritoneal carcinomatosis, or reactive mesothelial hyperplasia. Checking for certain biomarkers in a biopsy sample is another way to make a more accurate diagnosis.


Because WDPM is so rare, there is no standard treatment plan. Treatment strategy will vary individually. Surgery may remove a WDPM tumor, although some doctors feel this is an overly aggressive treatment strategy for a typically benign cancer.

Chemotherapy and radiation are other treatment options. However, results have been mixed. In one study, patients that received both treatments died. However, researchers were uncertain if the cause of death was the therapy or the tumors.


Determining a prognosis for WDPM is difficult because it is such a rare disease. Cases that have been studied resulted in varying survival rates, although generally the prognosis is better than for malignant mesothelioma. In one case study, a woman lived 24 years after diagnosis. Another study of 24 patients with pleural WDPM, survival times ranged from three to 15 years. In a case study of WDPM of the tunica vaginalis, the man was healthy and tumor-free four years after diagnosis.

Although WDPM is largely non-malignant, it can become malignant in some cases. It is important that patients understand that the rarity of the condition means definite answers are virtually impossible. Regular follow-up exams and screenings are important to ensure WDPM does not become malignant.

Page Edited by Dave Foster

Dave has been a mesothelioma Patient Advocate for over 10 years. He consistently attends all major national and international mesothelioma meetings. In doing so, he is able to stay on top of the latest treatments, clinical trials, and research results. He also personally meets with mesothelioma patients and their families and connects them with the best medical specialists and legal representatives available. Connect with Patient Advocate Dave Foster

Get Your FREE Resources Sent Overnight

  • New treatment options
  • Veterans benefits & claims
  • $30 Billion asbestos trust fund information

– Or Call –

Site Navigation

Where can I

Get Additional Help?

For over 20 years we’ve provided the best FREE resources to mesothelioma patients and loved ones. Our resources include information on the leading treatment options and best doctors in your area; lessons learned from survivors; claims and benefits specifically for Veterans; and how to access your share of billions of dollars in trust fund money.

Get Your FREE Resources Sent Overnight

  • New Treatment Options
  • Veteran's Benefits & Claims
  • $30 Billion Asbestos Trust Fund Information

– Or Call –

$30 Billion Asbestos Trusts
Get Started