Mesothelioma Causes

Asbestos Exposure Causes Mesothelioma

In recent decades, the association between long-term exposure to asbestos and the development of malignant mesothelioma cancer has become well-established. Although the latency period (or the time from initial asbestos exposure to the first display of symptoms of mesothelioma cancer) for mesothelioma is quite long, the majority of mesothelioma patients are people whose vocations involved repeated exposure to asbestos-containing materials over a lengthy time period.

Most people with mesothelioma worked in construction, shipyards, HVAC, or in vinyl manufacturing—all occupations which frequently involve working with materials that contain asbestos. Thus, most cases of malignant mesothelioma can establish a clear line between asbestos exposure and development of the cancer.

What Is Asbestos?

Asbestos is a naturally occurring mineral that has insulating and fire-retardant qualities, which is why is it is often used in industrial products and factories. Asbestos fibers exist in to primary forms, including serpentines and amphibole. In either case, this dangerous substance always consists of tiny fibers that are invisible to the naked eye. In fact, they are over a thousand times thinner than the average human hair. Though they are microscopic fibers, asbestos is strong and durable.

Recent Research Shows Factors Add to the Risk Posed by Asbestos Exposure

Although asbestos exposure is the most common cause of this rare cancer, recent research has come to light that indicates that asbestos is not the only factor which can influence mesothelioma development.

Genetic Factors

The ultimate cause of any type of cancer is mutations in DNA. DNA is the large molecule that contains all of the genes a person has. These can become mutated, or changed, sometimes randomly, other times triggered by things like radiation or asbestos fibers. Asbestos is thought to cause mutations in the DNA of the cells in the mesothelium, and this is what most likely leads to the development of cancer.

On the other hand, not everyone who inhales asbestos fibers will end up with mesothelioma or any type of cancer. This may mean that some people have genes that make them more susceptible to the damage and the mutations caused by asbestos. Research has found that people at high risk for mesothelioma have mutations in a gene called BAP1. This gene, when not changed, is responsible for helping cell growth remain under control. If that gene is damaged it could cause uncontrolled cell growth, or cancer.

Radiation Exposure

There have also been a few published cases of patients who developed mesothelioma after receiving considerable doses of radiation to the chest or abdomen, as part of treatment for another form of cancer. While the chances of a cancer patient developing mesothelioma after receiving radiation treatment are somewhat elevated, still these cases are rare. The reason that radiation can contribute to mesothelioma is that it mutates DNA.

The SV40 Virus

Simian virus 40, also known as SV40, is a virus that is found in both humans and other primates. Infection with the virus may not produce symptoms and may simply stay in the body for a long period of time. However, studies have found that it can also cause cancer in humans and animals. SV40 has been implicated as a possible risk factor for mesothelioma, although evidence is limited.

Between 1955 and 1963 some people who received the polio vaccine were accidentally given SV40. The vaccines had inadvertently been contaminated with the virus. Nearly 30 million people were exposed and some experts think this may have increased the risk of developing mesothelioma within this group.

Carbon Nanotube Inhalation

Carbon nanotubes are an up-and-coming molecule being used more and more often in the manufacture of goods that need to be simultaneously lightweight and strong (such as electronics, automotive parts, and sports equipment). Because the use of carbon nanotube technology is relatively new, little is known about the risks involved with long-term exposure to them. However, recent mesothelioma cases have developed in people who have worked in labs developing carbon nanotubes, and on production floors where items containing carbon nanotubes are manufactured, suggesting a link between carbon nanotube exposure and mesothelioma.

Other Risk Factors

Other risk factors should also be taken into account when considering the causes of mesothelioma. These factors may not directly cause mesothelioma, but they do seem to contribute to it. For example, people who smoke and who are exposed to asbestos are more likely to develop mesothelioma than non-smokers exposed to asbestos. Other risk factors include being male and being over the age of 45. Men in this age group are overwhelmingly the majority of mesothelioma patients.

Contact with a group of minerals called zeolites may also contribute to mesothelioma. These are minerals that, like asbestos, are naturally found in the earth. They are similar in chemical composition and structure to asbestos. Zeolites are more common in the soil of certain locations, including areas of Turkey. Higher incidences of mesothelioma in these areas are attributed to the presence of zeolites.

More Research is Needed

These recent findings suggest that more research should be conducted in order to investigate all he contributing factors to mesothelioma. This extended research could lead to precautionary measures being suggested and taken—measures that could potentially save lives by preventing unwitting exposure to asbestos, especially in those with other risk factors.

Being conscious of mesothelioma’s primary causes and risk factors increases a patient’s probability of catching the disease in its early stages. If you suspect that you or someone you know is at risk of developing mesothelioma based on their history, please seek medical attention as soon as possible. Symptoms and warning signs may be undetectable for many years and the sooner a doctor is able to make a diagnosis, the sooner the patient can begin seeking treatment.