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Pleural Thickening

Diffuse pleural thickening and is a disease of the lungs. and occurs extensive scar tissue causes the pleura to thicken. The pleura are membranes that line the chest cavity and lungs. Pleural thickening may be a symptom of mesothelioma and related conditions, or it may be benign.

Thickening of the pleural tissue can become severe, completely enclosing the lungs and filling in the space between the pleura and the lungs. It may cause difficulty breathing, shortness of breath, and chest pains. Pleural thickening is one of the most common conditions connected to asbestos exposure.

What Causes Pleural Thickening

While pleural thickening is a common result of asbestos exposure, asbestos is not the only cause of this condition. Pleural thickening can also be a symptom of another illness. When someone is exposed to asbestos over a long period of time, the fibers of this mineral often lodge in tissues like the lungs and pleura. In the pleura, asbestos fibers can trigger inflammation, resulting in fibrous scar tissue and collagen deposits. Pleural thickening caused by asbestos is often benign but may also be caused by malignant mesothelioma.

Another medical condition that causes pleural thickening is a type of inflammation called fibrinous pleuritic and empyema. This condition is an accumulation of mucus in the space between the pleura. A pulmonary embolism, a blood clot in the vessels leading to the lungs, may also cause pleural thickening.

Localized areas of thickening are called pleural plaques. These are not the same as diffuse pleural thickening. Plaques may precede malignant tumors and do not cause symptoms like difficulty breathing.


Pleural thickening is progressive, worsening with time In earlier stages, it may not cause many symptoms, much like mesothelioma. This is why anyone exposed to asbestos should be screened early and often. As thickening worsens, a person may experience shortness of breath,breathlessness, and chest pains.

When pleural thickening becomes severe, it may lead to a condition called restrictive lung disease. This occurs when the lungs become so encased in fibrous scar tissue that they cannot fully expand. This causes decreased lung volume and forces the patient to work harder just to breathe. When this condition becomes severe, it can lead to respiratory failure and death.


Pleural thickening does not develop in everyone who is exposed to asbestos, but it is not uncommon. If you were exposed to asbestos on the job, regular screening for lung problems is important.  Diagnosis for pleural thickening usually begins with a description of symptoms, which include shortness of breath, breathlessness, and chest pains combined with known asbestos exposure.

After a physical exam, the next step is imaging the chest cavity. Imaging scans can show thickening, plaques, and other abnormalities in the chest. A chest X-ray is a typical first screening, although it may not show everything necessary for diagnosis. A CT, or computed tomography scan, gives a clearer picture of what is happening in the lungs and pleura. These scans are high resolution and allow doctors to distinguish between pleural thickening and pleural plaques.

Distinguishing between benign pleural thickening and malignant mesothelioma is not easy. A doctor may choose to follow a CT scan with a PET scan (positron emission tomography) to help determine if thickening is benign or cancerous. While this may not be enough for a firm diagnosis, it can determine if a biopsy is necessary. If pleural thickening is greater than one centimeter or there are nodules in the tissue, these are signs the thickening is malignant.


Early diagnosis is important because pleural thickening is progressive. It will only worsen without treatment. If caused by mesothelioma, early treatment is especially important. Damage caused pleural thickening cannot be reversed, though treatment can slow progression and relieve symptoms.

Pain medication is a common treatment for benign pleural thickening. A doctor may also prescribe bronchodilators to dilate airways. In addition, a patient may receive steroids to reduce inflammation.

Decortication surgery can remove some of the restrictive fibrous scar tissue. However, this is not a common procedure, especially if the thickening is related to other asbestos conditions like mesothelioma. Few mesothelioma patients are good candidates for surgical treatment, but for those who are, surgery can relieve symptoms of pleural thickening.

Other treatment strategies include respiratory aides, like oxygen tanks and respirators.


The outlook for diffuse pleural thickening is highly dependent on several factors. If the underlying condition can be treated, the outlook is typically positive. If the underlying cause is mesothelioma, prognosis is poor. Mesothelioma is challenging to treat and nearly incurable. Treatments at an early stage may be successful at relieving symptoms and slowing the progression of damage to the pleura. Unfortunately, reversing the damage is not possible.

If you have been diagnosed with pleural thickening and believe you were exposed to asbestos, talk to your doctor about the possibility of mesothelioma. Insist on screening for this type of cancer, but also understand what your options are for treating the symptoms of pleural thickening. With treatment and good management, you can experience some relief from this uncomfortable condition.

Page Edited by Dave Foster

Dave has been a mesothelioma Patient Advocate for over 10 years. He consistently attends all major national and international mesothelioma meetings. In doing so, he is able to stay on top of the latest treatments, clinical trials, and research results. He also personally meets with mesothelioma patients and their families and connects them with the best medical specialists and legal representatives available. Connect with Patient Advocate Dave Foster

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