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Page Updated: April 01, 2022

Clinical Trials for Mesothelioma Treatment: What to Expect

Luis Argote-Greene, MD Page Medically Reviewed and Edited by Luis Argote-Greene, M.D.
Fact Checked

This page has been fact checked by a Medical Doctor who specializes in mesothelioma. Sources of information are listed at the bottom of the article.

We make every attempt to keep our information accurate and up-to-date.

Please Contact Us with any questions or comments.

Clinical trials for mesothelioma treatments provide patients with the opportunity to try new, unapproved therapies. The purpose of a clinical trial is to test the efficacy and safety of new therapies and diagnostic techniques. They also provide patients with additional options and hope for better outcomes.

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What Are Clinical Trials?

A clinical trial uses human participants to test novel therapies, treatment procedures, and medications. Treatment is administered to a select group of people, and researchers monitor the results. Researchers use this information to establish the safety and effectiveness of that treatment for a given disorder.[1]

For clinical trials related to mesothelioma, the process usually involves a “testing out” of a given chemotherapy drug.

There are potential risks for both standard therapy and drugs used in clinical trials. Treatments studied are experimental, and the trial’s purpose is to determine both treatment safety and effectiveness.[1]

However, the risks are often considered worth the potential benefits for people with aggressive cancer like mesothelioma.

Qualifying for Clinical Trials

Each trial has a specific set of criteria that potential participants must meet to qualify as a participant. Those who meet the criteria may participate. Criteria often vary widely from one clinical trial to another.[2]

Some trials involve people from specific demographics (such as people of a particular gender or age range). Some trials will focus on participants with a certain type of mesothelioma.

For example, a trial may be conducted to determine the safety and efficacy of a new drug for malignant pleural mesothelioma, but not pericardial or peritoneal mesothelioma. As a first step, patients who wish to participate can expect a questionnaire to determine if they meet the trial’s qualification requirements.

The Clinical Trial Process

The process for all clinical trials is generally the same. To meet approval guidelines set by the FDA, each trial must be conducted according to experimental research standards; thus, whether the trial is studying a chemotherapy drug or a novel multi-modal treatment approach, it will be conducted like other clinical trials.

Clinical Trials Mobile

Clinical Trial Phases

There are always at least three phases to a clinical trial. Often a fourth phase is conducted, even after FDA approval has been secured and treatment made available to the general public.[3]

Phase 1:
The initial phase involves administering the proposed treatment to a very small subset of the intended treatment population. In this phase, dosages and treatment administration methods are established. Also, the first reports of side effects are recorded.[3]

Phase 2:
The second clinical trial phase expands the number of people receiving treatment, using guidelines for dosage and administration established in phase I. In this phase, the effectiveness of the treatment is studied in more detail.[3]

Phase 3:
The third clinical trial phase again expands the number of participants and involves creating a control group. The control group is given a placebo rather than the novel treatment being studied. The placebo may be a treatment that has already been approved for use.

The control group allows researchers to compare the treatment to standard treatments. If the results for the new treatment are positive, the FDA may approve it to treat malignant mesothelioma.[3]

Phase 4:
The fourth and final clinical trial phase continues to study the new treatment, looking specifically for long-term risks and additional benefits. This phase often occurs after FDA approval, and it may last for years or even decades.[3]

What Are the Benefits of Participating in Clinical Trials?

While participating in clinical trials to help further medical knowledge is altruistic, it is not realistic. The real motivation for participation is to benefit from a novel treatment or intervention. This is especially important for patients with an incurable disease, like late-stage mesothelioma.

If you have mesothelioma, you may have little hope of a cure; however, one of those small hopes may be through a clinical trial. Although rare, the intervention tested may provide a cure for the disease.

Are Clinical Trials Risky?

There are also risks involved with clinical trial participation. These are drugs and treatments that have not yet been tested on people. The participants are essentially human guinea pigs; however, there are protections, including informed consent.

Participants must be provided with all necessary information before agreeing to participate in the study. There are also institutional review boards that monitor and approve studies. This ensures clinical trials proceed ethically. Patients may opt out at any time and are not obligated to stay enrolled in the clinical trial.[2]

Even with these measures in place, there are risks. For instance, you may not even get to try the new treatment. Randomized, blind studies only assign the novel treatment to some participants.[4] Other risks are related to the newness of the intervention. There may be side effects and complications no one has yet foreseen.

Is Curing Mesothelioma Possible in a Clinical Trial?

Many patients who qualify for clinical trials are in the later stages of the disease or have not responded to other treatments. Remission for these patients is extremely unlikely.

Will Clinical Trials Find a Cure for Mesothelioma?

It is possible that a clinical trial will one day contribute to finding a cure for mesothelioma. However, curing mesothelioma is not usually the focus of clinical trials. Because of how mesothelioma grows and spreads, researchers concentrate on managing the disease and giving patients a longer life expectancy.

Do Patients Have to Pay to Be in Clinical Trials?

Every trial is different, but usually, patients do not pay for their treatments. A sponsor, such as a drug manufacturer or the federal government, typically pays the costs.

Participants can expect to pay for any routine, non-experimental treatments and diagnostics. These are the standard procedures, therapies, and tests you would receive as part of care anyway. You can apply insurance benefits to these costs.

What to Expect When Participating in a Mesothelioma Clinical Trial

The first step in joining a clinical trial is to determine eligibility. The trial staff will ask you questions and explain the trial and requirements. After enrolling, participants go through several steps:

  1. Informed Consent. The researchers must explain all aspects of the study to you before you participate. You then must sign a form to ensure you understand what to expect. This is known as informed consent, and it is an ethical necessity. Patients must understand the benefits and risks before joining.
  2. Baseline Exam. The next step is to undergo a physical exam and other tests, such as a blood test. This gives the researchers a baseline for your health and the status of your cancer before the experimental treatment.
  3. Assignment to a Group. Most trials include an experimental group and a control group. Cancer trials rarely use a placebo for the control group. Instead, they offer standard cancer treatment. The assignment is random.
  4. Receive Treatment. Finally, you begin treatment. The doctors and nurses will evaluate you regularly throughout. You will undergo more diagnostics and screenings than usual because they need to monitor your progress. They will also ask you questions about symptoms and side effects.

Patients are allowed to leave a clinical trial at any time and for any reason. This is your right as a voluntary participant. Some trials end early as well. Side effects or poor results can end a trial.

Examples of New Mesothelioma Treatments Tested in Clinical Trials

To find clinical trials, talk to your oncologist and other members of your medical team. Your doctors will likely know where to find a clinical trial in your area. They may be able to get you started, helping fill out application paperwork to get the ball rolling.

These are some of the important mesothelioma clinical trials completed or ongoing. Many are recruiting patients right now.

VISTA Protein Clinical Trials

Researchers from Curis, Inc. recently completed a phase I clinical trial for a new drug called CA-170. This is the first drug to target the checkpoint protein VISTA, which is strongly expressed in mesothelioma tumors. The drug also targets PD-L1, another checkpoint protein.

The drug is designed to interfere with the interaction between these proteins in cancer cells and matching proteins on immune system T-cells. When the interaction is prevented, it may trigger immune cells to attack the cancer cells.[5]

Nivolumab and Ipilimumab Clinical Trials

A combination of nivolumab and ipilimumab became the first immunotherapy treatment approved by the FDA to treat pleural mesothelioma after successful clinical trials. This combination triggers the immune system to find and kill cancer cells. A clinical trial testing the combination for rare cancers is ongoing and recruiting peritoneal mesothelioma patients.[6]

Durvalumab Clinical Trials

Mesothelioma patients with the pleural, nonresectable form of cancer are currently participating in clinical trials with the immunotherapy drug durvalumab. The drug targets proteins on the surface of cancer cells, effectively allowing the immune system to recognize them as harmful.

The immune cells can then destroy more cancer cells. The trials include the use of durvalumab along with chemotherapy and other immunotherapy drugs. Some of the results of these trials have been promising, and if they continue to go well, durvalumab could become an approved drug for managing mesothelioma.[7]

Anetumab Ravtansine Clinical Trials

Anetumab ravtansine is an experimental immunotherapy drug known as an antibody-drug conjugate. It uses an engineered antibody to target specific cancer cells and deliver a cytotoxic drug.

This particular immunotherapy drug targets cancer cells that overexpress the protein mesothelin, including cells in many mesothelioma, ovarian, and pancreatic tumors. Clinical trials are ongoing to test how effective the drug is compared to chemotherapy and in combination with chemotherapy or other immunotherapies.[8]

Atezolizumab Clinical Trials

The immunotherapy drug atezolizumab is currently being tested in clinical trials with mesothelioma patients. It is already approved for certain patients with bladder cancer and non-small cell lung cancer. Atezolizumab is also known as Tecentriq and is made by Genentech.

It is a PD-L1 checkpoint inhibitor and works by interacting with this protein on cancer cells. By binding to PD-L1, atezolizumab prevents the cancer cells from hiding from the body’s immune system. Once unmasked by the drug, cancer cells can be attacked by immune system T-cells.[9]

Chimeric Antigen Receptor (CAR) T-Cell Clinical Trial

CAR T-Cell therapy is a new therapeutic strategy that involves removing a patient’s immune system T-cells, altering them, and re-injecting them to kill cancer cells. Already approved for some types of blood cancers, CAR T-cell treatment uses genetic engineering to alter T-cells.

The T-cells are then prepared to multiply in the patient’s body, find and latch onto cancer cells and kill them. A new version of this therapy targeting mesothelin proteins in cancers like mesothelioma has been tested in a phase I U.S. clinical trial.[10]

Immunotoxin Clinical Trials

Immunotoxin drugs are proteins that attach to toxins, like chemotherapy drugs. The proteins are antibodies, like those produced by the body’s immune system. The antibodies find and attach to proteins on cancer cells and get absorbed. Once inside the cancer cell, the toxin can kill it.

Clinical trials are currently ongoing to test the effectiveness of immunotoxins, often combined with other drugs. Some trials are recruiting patients with pleural and peritoneal mesothelioma.[11]

Interferon Alfa-2b Clinical Trials

Interferon Alfa-2b is a gene that can be added to viral cells and then injected into patients with certain viral infections and types of cancer. The gene creates a protein of the same name that helps signal immune cells against viruses and cancer cells.

Trizell is currently recruiting pleural mesothelioma patients for a phase III clinical trial using their novel drug TR002, a form of interferon alfa-2b gene therapy. This comes after a successful phase II trial that extended the survival times of many of the participants.[12]

How to Enroll in a Clinical Trial

The best way to get involved in a mesothelioma clinical trial is to speak to your medical team about it. They know which trials need patients. They can also find out the eligibility requirements and determine if you qualify. Check out the National Cancer Institute website for a list of current trials investigating new mesothelioma treatments.[13]

If you hope to participate in a clinical trial for treating any type of mesothelioma, be sure you understand the risks. Always talk to your medical team before deciding to participate in an experimental treatment. You need to be sure you are eligible and willing to take risks associated with an untested medical treatment.

For many mesothelioma patients, this is an easy choice. Mesothelioma is an aggressive cancer with no known cure; therefore, seeking a clinical trial with a novel treatment is often a smart option. Talk to your doctors and family members before making a final decision.

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Page Medically Reviewed and Edited by
Luis Argote-Greene, M.D.

Luis Argote-Greene, MD

Luis Argote-Greene is an internationally recognized thoracic surgeon. He has trained and worked with some of the most prominently known thoracic surgeons in the United States and Mexico, including pioneering mesothelioma surgeon Dr. David Sugarbaker. He is professionally affiliated with University Hospitals (UH). His areas of interest and expertise are mesothelioma, mediastinal tumors, thoracic malignancies, lung cancer, lung transplantation, esophageal cancer, experimental surgery, and lung volume reduction. Dr. Argote-Greene has also done pioneering work with video-assisted thoracoscopic surgery (VATS), as well as robotic assisted minimally invasive surgery. He has taught the procedures to other surgeons both nationally and internationally.

Connect with Mesothelioma Doctor Luis Argote-Greene, M.D.
References
  1. American Cancer Society. (2016, May 3). The Basics of Clinical Trials.
    Retrieved from: https://www.cancer.org/treatment/treatments-and-side-effects/clinical-trials/what-you-need-to-know/clinical-trial-basics.html
  2. National Institutes of Health. U.S. National Library of Medicine. (2017, January). Learn about Clinical Studies.
    Retrieved from: https://clinicaltrials.gov/ct2/about-studies/learn
  3. American Cancer Society. (2017, February 7). What Are the Phases of Clinical Trials?
    Retrieved from: https://www.cancer.org/treatment/treatments-and-side-effects/clinical-trials/what-you-need-to-know/phases-of-clinical-trials.html
  4. National Cancer Institute. (n.d.). Blinded Clinical Trial.
    Retrieved from: https://training.seer.cancer.gov/treatment/other/trial.html
  5. National institutes of Health. (2019, May 6). A Study of CA-170 (Oral PD-L1, PD-L2 and VISTA Checkpoint Antagonist) in Patients With Advanced Tumors and Lymphomas.
    Retrieved from: https://clinicaltrials.gov/ct2/show/NCT02812875
  6. National Cancer Institute (NCI). (2022, January 31). Nivolumab and Ipilimumab in Treating Patients With Rare Tumors.
    Retrieved from: https://clinicaltrials.gov/ct2/show/NCT02834013
  7. PrECOG, LLC. (2022, January 25). DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma (DREAM3R).
    Retrieved from: https://clinicaltrials.gov/ct2/show/NCT04334759
  8. National Cancer Institute (NCI). (2021, December 3). Pembrolizumab With or Without Anetumab Ravtansine in Treating Patients With Mesothelin-Positive Pleural Mesothelioma.
    Retrieved from: https://clinicaltrials.gov/ct2/show/NCT03126630
  9. Gruppo Oncologico Italiano de Ricerca Clinica (2021, August 16). Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso) (AtezoMeso).
    Retrieved from: https://clinicaltrials.gov/ct2/show/NCT04996017
  10. Adusumilli, P.S., Zauderer, M.G., Riviere, I., Solomon, S.B., Rusch, V.W., O’Cearbhaill, R.E., Zhu, A., Cheema, W., Chintala, N.K., Halton, E., Pineda, J., Perez-Johnston, R., Tan, K.S., Daly, B., Araujo Filho, J.A., Ngai, D., McGee, E., Vincent, A., Diamonte, C., Sauter, J.L., Modi, S., Sikder, D., Senechal, B., Wang, X., Travis, W.D., Gonen, M., Rudin, C.M., Brentjens, R.J., Jones, D.R., and Sadelain, M. (2021, November). A Phase I Trial of Regional Mesothelin-Targeted CAR T-cell Therapy in Patients with Malignant Pleural Disease, in Combination with the Anti–PD-1 Agent Pembrolizumab. Cancer Discov. 11(11). DOI: 10.1158/2159-8290.CD-21-0407.
    Retrieved from: https://cancerdiscovery.aacrjournals.org/content/11/11/2748.full-text.pdf
  11. National Cancer Institute (NCI). (2021, December 27). Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma.
    Retrieved from: https://clinicaltrials.gov/ct2/show/NCT04840615
  12. PR Newswire. (2019, March 20). Trizell Ltd. Announces Phase 3 Pivotal Study of Interferon alfa-2b Gene Therapy in Malignant Pleural Mesothelioma.
    Retrieved from: https://www.prnewswire.com/news-releases/trizell-ltd-announces-phase-3-pivotal-study-of-interferon-alfa-2b-gene-therapy-in-malignant-pleural-mesothelioma-300815572.html
  13. National Cancer Institute. (n.d.). Treatment Clinical Trials for Mesothelioma.
    Retrieved from: https://www.cancer.gov/about-cancer/treatment/clinical-trials/disease/mesothelioma/treatment
View All References
Jump To a Topic
  • What Are Clinical Trials?
  • Qualifying for Clinical Trials
  • The Clinical Trial Process
  • What Are the Benefits of Participating in Clinical Trials?
  • Are Clinical Trials Risky?
  • Is Curing Mesothelioma Possible in a Clinical Trial?
  • Will Clinical Trials Find a Cure for Mesothelioma?
  • Do Patients Have to Pay to Be in Clinical Trials?
  • What to Expect When Participating in a Mesothelioma Clinical Trial
  • Examples of New Mesothelioma Treatments Tested in Clinical Trials
  • How to Enroll in a Clinical Trial
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