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Types of Mesothelioma
Comparison and Contrast

Malignant mesothelioma is an extremely uncommon and aggressive type of cancer. It is generally associated with exposure to asbestos, a carcinogenic fibrous mineral. Most victims of exposure were had contact with asbestos in the workplace. Mesothelioma is unique in that is has an unusually long latency period, so the time from first exposure to a carcinogen to becoming symptomatic may span decades, a half a century, or longer. Most of those who are diagnosed with mesothelioma have a form that impacts the lungs, but there are other types too.

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What Types of Mesothelioma Are There?

Malignant mesothelioma is the name of a specific type of cancer which may occur in the lining of tissue around the lungs (pleural mesothelioma), abdominal cavity (peritoneal mesothelioma), heart (pericardial mesothelioma) or testis (paratesticular mesothelioma).

Mesothelioma can also take the form of different cell types: epithelial mesothelioma occurs strictly in the epithelial cells of the mesothelium, whereas sarcomatoid mesothelioma manifests in lengthened, spindle-shaped cells and can be difficult to tell apart from healthy tissue and thus. Some mesotheliomas involve a combination of the two cell types, and these are called biphasic.

How Do the Mesothelioma Types Differ?

The types of mesothelioma differ in regard to which cell types they produce and affect and which parts of the body they initially afflict. Pleural and peritoneal mesothelioma may be more easy to treat than pericardial and paratesticular mesothelioma.

Also, in terms of cell types epithelial mesothelioma is generally regarded as being less difficult to treat than sarcomatoid or biphasic mesothelioma. The shape and location of the sarcomatoid cells make them difficult to differentiate from normal, healthy cells.

How Are They the Same?

All types of mesothelioma have a few things in common: t

  • They are aggressive cancers. The speed at which mesothelioma tends to grow and spread is very swift compared with other forms of cancer.
  • All types of mesothelioma affect the mesothelium, a thin layer of tissue found in different parts of the body.
  • Also, all mesotheliomas have long latency periods—a person who was exposed to asbestos may not experience symptoms and be diagnosed until long after he or she has reached retirement age, decades later.

Pleural Mesothelioma

By far the most common type of mesothelioma is pleural, accounting for about 75 percent of all diagnosed cases of this. Pleural mesothelioma is cancer of the pleura, the part of the mesothelium that lines the lungs.

Because it occurs so close to the lungs, this type of mesothelioma is often mistaken for lung cancer. It is also likely the most common type because most cases of mesothelioma is triggered by inhalation of asbestos fibers, which get lodged in the lungs and pleural tissue and cause damage.

Although it is the most common type of mesothelioma, pleural mesothelioma is still rare. Lung cancer, which can also be caused by asbestos exposure, is much more common. For these reasons, pleural mesothelioma is often misdiagnosed as a type of lung cancer, but also often as pneumonia, bronchitis, and other common conditions.

Symptoms of pleural mesothelioma include chest pain. This is caused by the buildup of fluid in the pleural space, called pleural effusion. Other symptoms reported include a chronic, sometimes painful cough, weight loss and fever, and shortness of breath. Too often these symptoms are mistaken for another health condition and diagnoses of pleural mesothelioma come after the disease has progressed to a late stage.

Peritoneal Mesothelioma

The second most common type of mesothelioma affects the peritoneum. This is the part of the mesothelium that lines the abdominal space. Between ten and 20 percent of mesothelioma cases are peritoneal. Inhalation of asbestos more often leads to pleural mesothelioma and other respiratory conditions, but the fibers can travel to the abdomen after inhalation. Peritoneal mesothelioma may also be triggered by accidental ingestion of asbestos.

Symptoms of peritoneal mesothelioma may include swelling and pain in the abdomen from fluid accumulation, bowel obstructions and constipation, anemia, weight loss, and fever. It may be misdiagnosed as a more common gastrointestinal condition, like irritable bowel syndrome.

Pericardial Mesothelioma

Very rare is pericardial mesothelioma, a cancer of the lining of the heart. Only about 150 cases of confirmed diagnosis of this type have ever been reported. It is common in older patients and in male patients. Symptoms of pericardial mesothelioma include chest pains, difficulty breathing, a chronic cough, an irregular heartbeat, fluid buildup around the heart, and a mass between the lungs. It may be

misdiagnosed as a type of heart disease or heart failure.

Testicular Mesothelioma

The rarest of all types of mesothelioma affects the testicles in men. It is so rare that fewer than 100 cases have been reported. The official name of this type of cancer is tunica vaginalis testis mesothelioma, and it is the cancer of the mesothelium that lines the testes. Most of the few reported cases were in men over 50, but there have also been cases of men younger than 25 developing this type of cancer.

The symptoms reported include a lump that can easily be mistaken for a hernia. With so few cases, though, there are not many other symptoms considered to be common. The prognosis for this type of mesothelioma is better than the others because surgical removal often cures it.

Benign vs. Malignant Mesothelioma

Nearly all cases of mesothelioma are malignant, which means cancerous and with the potential to metastasize or spread to other locations. Benign tumors do not spread, and while they may cause complications, discomfort, or pain, are not considered cancerous or life-threatening. Benign mesothelioma is rare, and in fact is not even always classified as mesothelioma.

Misleadingly called benign mesothelioma, this type of tumor is more accurately called a solitary fibrous tumor of the pleura, peritoneum, or other part of the mesothelium. It is called solitary because it usually grows as one lump, whereas malignant mesothelioma tumors grow as multiple smaller nodules. Treatment is straightforward, usually by surgical procedure, and the prognosis is generally good.

Different Cell Types in Mesothelioma

Each type of mesothelioma may affect different types of cells. Depending on which cell types are afflicted with the cancer, the mesothelioma is said to be epithelial, sarcomatoid, or biphasic. Each of these mesothelioma types come with prognostic implications, with some types being more common than others and some types being more easily treated than others.

Epithelioid Cells
Pathologists can look at cells from a mesothelioma tumor biopsy and describe them as either epithelioid, sarcomatoid, or biphasic. Epithelioid mesothelioma is the most common type, accounting for as much as 70 percent of cases.

These types of cells are easiest to treat and this type of mesothelioma has the highest survival rates. This is because the epithelioid cells, as compared to others, adhere more closely to each other. They are less likely to spread from a tumor and do so more slowly. There are several subtypes of epithelioid cancer cells that can be used to further classify a diagnosis.

Sarcomatoid Cells
Sarcomatoid mesothelioma cells are much less common than epithelioid cells. Only about ten to 20 percent of diagnosed cases of pleural mesothelioma and four percent of peritoneal mesothelioma are of this type.

Sarcomatoid cells are much more aggressive, detach from each other more easily, and are more likely to spread, and spread faster than malignant epithelioid cells. Treating sarcomatoid mesothelioma is more difficult due to the aggressive tendency of the cells to metastasize. The prognosis is much less positive for most patients with this diagnosis.

Biphasic Cells
When a pathologist finds both types of cells, epithelioid and sarcomatoid, in a cell sample from a mesothelioma tumor, the cancer is classified as biphasic. This accounts for about 20 to 30 percent of cases of mesothelioma. The amount of each type of cell varies by patient. This means that prognosis and survival rates are varied. The more epithelioid cells there are, the better the prognosis.

Diagnosis of mesothelioma is challenging. Understanding the different types of mesothelioma is important in making a more accurate diagnosis, being able to stage the cancer correctly, and being able to plan the best course of treatment. If you suspect you may have one of these types of mesothelioma, even one of the very rare types, don’t hesitate to talk to your doctor about your concerns and your symptoms.

Treating Different Types of Malignant Mesothelioma

The typical treatment methods for mesothelioma include surgery, radiation therapy, chemotherapy and novel therapies such as those explored in clinical trials. Different types of mesothelioma respond better to different types of treatment. In many cases a multi-therapy approach using two or three types of treatment is the best option.

Epithelial mesothelioma can often be treated with surgery, as the cancerous cells are easier to spot with the naked eye in order for a surgeon to remove them from the body. Often, surgery is combined with chemotherapy or radiation treatment—either before, during or after surgery—in an effort to eliminate cancerous cells that the surgery may not have completely eradicated. Epithelial mesothelioma is considered the most treatable form of this cancer, with the most options open for different treatment methods.

Sarcomatoid mesothelioma can be extremely difficult to treat using surgical means, as the cells become very stiff and rigid and tend to embed themselves firmly into a patient’s internal organs. For this reason, chemotherapy and radiation treatments are the most popular options for this form of cancer. In many cases, sarcomatoid mesothelioma treatments are palliative rather than curative due to the aggressive spread involved in this cancer type.

Biphasic mesothelioma can be treated with surgery, chemotherapy, radiation, or a multimodal approach combining various treatment types. For example, the epithelial cancer may be removed surgically while the sarcomatoid cancer may be targeted with chemotherapy and radiation treatment. Treatments for biphasic mesothelioma may be both curative and palliative, depending on the extent of growth and spread of the cancer. This form of mesothelioma has a better prognosis than the sarcomatoid form, but not as promising a prognosis as most epithelioid mesothelioma diagnoses.

Understanding mesothelioma types is important for diagnosis and treatment but also for the patient to know what to expect. If you have questions about your diagnosis, the type of  mesothelioma, or any concerns about mistakes or misdiagnosis, don’t hesitate to speak up, ask questions, or get a second opinion.

Page Edited by Dave Foster

Dave has been a mesothelioma Patient Advocate for over 10 years. He consistently attends all major national and international mesothelioma meetings. In doing so, he is able to stay on top of the latest treatments, clinical trials, and research results. He also personally meets with mesothelioma patients and their families and connects them with the best medical specialists and legal representatives available. Connect with Patient Advocate Dave Foster

Page Medically Reviewed and Edited by
Luis Argote-Greene, MD

Luis Marcelo Argote-Greene, MD
Luis Argote-Greene is an internationally recognized thoracic surgeon. He has trained and worked with some of the most prominently known thoracic surgeons in the United States and Mexico, including pioneering mesothelioma surgeon Dr. David Sugarbaker. He is professionally affiliated with University Hospitals (UH). His areas of interest and expertise are mesothelioma, mediastinal tumors, thoracic malignancies, lung cancer, lung transplantation, esophageal cancer, experimental surgery, and lung volume reduction. Dr. Argote-Greene has also done pioneering work with video-assisted thoracoscopic surgery (VATS), as well as robotic assisted minimally invasive surgery. He has taught the procedures to other surgeons both nationally and internationally.

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