Paraplatin (carboplatin)
Page Medically Reviewed and Edited by Kyle J. Becker, PharmD, MBA, BCOP This page has been fact checked by a Doctor of Pharmacy who specializes in Oncology. Sources of information are listed at the bottom of the article.
We make every attempt to keep our information accurate and up-to-date.
Free Mesothelioma Packet
- New treatment options
- Learn from survivors
- Veterans benefits & claims
- File for your share of $30 billion in trust funds
Please Contact Us with any questions or comments.
Paraplatin (carboplatin), a chemotherapy drug, treats several cancers through intravenous administration every one to three weeks. Carboplatin typically causes less severe side effects than cisplatin. It is an important chemotherapy drug for mesothelioma patients and is often used in combination with other drugs.
What Is Carboplatin?
Drugmakers developed and patented carboplatin in the 1970s. The U.S. Food and Drug Administration (FDA) did not approve this platinum-based chemotherapy drug until 1986, nearly a decade after the similar drug, cisplatin, came market.
Free Mesothelioma Packet
- New treatment options
- Learn from survivors
- Veterans benefits & claims
- File for your share of $30 billion in trust funds
Carboplatin was derived from cisplatin, its parent drug; therefore, the two drugs have similar properties and uses. Paraplatin is made by Bristol-Myers Squibb, while generic carboplatin could be made by Hospira, Teva Pharmaceuticals, and other companies.
Like cisplatin, carboplatin works by targeting and interfering with how rapidly-growing cells divide and thrive.[1]
Unfortunately, this drug does not differentiate between cancer cells and other healthy cells that grow and divide quickly. The lack of specificity and the presence of platinum cause several potential side effects. Carboplatin is used for a multitude of cancer types, including ovarian, mesothelioma, and lung cancer.
Carboplatin is administered through intravenous infusion. The procedure takes about fifteen minutes to an hour for each dose, and an infusion is administered every four weeks. A doctor or nurse administers carboplatin in a medical facility.[1]
Carboplatin for Mesothelioma
Although the FDA has not approved carboplatin for mesothelioma treatment. Still, it is a popular choice because the National Comprehensive Cancer Network (NCCN) recommends it, especially when used with other chemotherapy drugs.
Patients may easily develop a resistance to carboplatin when it is used alone. Combining carboplatin with other drugs can reduce resistance, often improving the response to treatment.
A common drug combination for pleural mesothelioma is carboplatin with pemetrexed, also known as Alimta.[2] Cisplatin has also been shown to be effective with pemetrexed. Some studies have shown that both combinations result in similar outcomes.
Doctors choose the specific combinations based on how the patient tolerates each drug and any preexisting conditions such as kidney damage.
Recent trials tested carboplatin with Alimta in elderly patients with mesothelioma. The results showed that elderly patients tolerated the combination nearly as well as a younger group of participants. The older patients also had similar disease outcomes and survival times.[3]
Additional studies tested the combination of carboplatin and pemetrexed with a third drug, bevacizumab. Bevacizumab is an anti-angiogenesis agent that works differently from chemotherapy by slowing the growth of new blood vessels to the tumor.
The trial was non-randomized and therefore had limitations; however, the strength of other trials using bevacizumab with cisplatin and pemetrexed have led the NCCN to recommend using this third agent when patients are no longer eligible for surgery.[4]
Common Side Effects of Carboplatin
Carboplatin is often preferred over cisplatin because some patients tolerate it better. Side effects are not only uncomfortable for the patient but may also limit medication dosage. Administering the full dose of chemotherapy is important to help treat the cancer as effectively as possible.
Carboplatin causes common side effects, including:[1]
- Nausea
- Diarrhea
- Vomiting
- Constipation
- Mouth sores
- Pain and tingling in hands and feet
- Skin irritation at the injection site
- Pain
- Weakness
- Hair loss
- Change in the taste of food
An additional advantage of carboplatin over cisplatin is that it does not often cause toxicity in the kidneys, a serious potential complication of cisplatin.
Carboplatin Black Box Warnings
The FDA uses a special warning label on medications for the most severe and life-threatening side effects and complications. Carboplatin comes with a few black box warnings. Both patients and doctors should weigh the risks and consequences of the potential benefits of this drug:
- One serious warning for carboplatin is that it can suppress the bone marrow. The risk of this side effect increases with dosage. The bone marrow produces new blood cells, so suppression can lead to anemia, bleeding, and infections. These side effects can be severe enough to require blood transfusions.[1]
- Another black box warning is aimed at patients with severe allergies to carboplatin injections. These patients may suffer anaphylactic shock, which can be fatal without immediate treatment. Signs of a severe reaction include hives and irritation at the injection site, swelling in the face, mouth, and throat, and difficulty breathing. These severe reactions may not be discovered until after the first dose. For this reason, carboplatin is only administered by healthcare professionals in an infusion center.
The Latest Carboplatin Research
Although it has been on the market for decades, mesothelioma researchers continue to investigate the effectiveness of therapies including carboplatin:
- In 2014, researchers compared the use of carboplatin with mitomycin in treating peritoneal mesothelioma patients with HIPEC. They found carboplatin gave better results, including shorter hospital stays and longer survival times.[5]
- Researchers reported in 2021 on the results of a comparison between carboplatin and cisplatin in pleural mesothelioma patients. This large study showed that carboplatin results in a comparable survival time.[6]
- Two clinical trials involving carboplatin as part of therapy are recruiding mesothelioma patients. One is to investigate the use of radiation with standard chemotherapy and the other is testing chemotherapy with immunotherapy drugs.[7]
Carboplatin is a drug that was developed from cisplatin. Although these drugs are similar, there are significant differences. Some patients tolerate carboplatin better, but it still comes with serious risks. The worst risk is the drastic reduction in blood cells, resulting in anemia and a weakened immune system.
Patients with mesothelioma may be given carboplatin if they cannot tolerate cisplatin. It will provide good results for many of these patients, especially when taken in combination with other drugs.
Page Medically Reviewed and Edited by Kyle J. Becker, PharmD, MBA, BCOP
Kyle J. Becker, PharmD is certified by the Board of Pharmacy Specialties in Oncology Pharmacy. Dr. Becker earned his pharmacy degree from Shenandoah University and he currently serves as an oncology pharmacist at Parkview Cancer Institute.