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Mesothelioma and Lung Cancer

Although the symptoms of mesothelioma and lung cancer are similar, they are not the same disease. Mesothelioma and lung cancer are diagnosed and treated very differently. Therefore, it is important to understand the fundamental differences between the two.

Lung Cancer, What is it?

Lung cancer is an abnormal growth of cells (cancer cells) in one or both lungs. Lymph nodes may or may not be involved. When abnormal cells begin to divide and grow rapidly, they can cause a variety of symptoms. When these symptoms become severe, they may interfere with daily activities. Common symptoms of lung cancer include shortness of breath, cough, decreased oxygenation, and/or chest discomfort.

Types and Staging

Lung cancer can be divided into two main categories: small cell and non-small cell. Almost 85 percent of all lung cancer cases Most cases are non-small cell lung cancer. Non-small cell lung cancer can be divided in stages (I, II, IIIA, IIIB, IV).

This cancer can also be divided into three forms. Adenocarcinoma (most common), squamous cell (also called epidermoid), and large cell. Adenocarcinoma is the type most commonly associated with non-smokers. Although smoking is the leading cause of lung cancer, it is not the only cause.

Though less common, small cell lung cancer is much more aggressive. It grows and spreads rapidly and should be treated immediately. Small cell lung cancer is not staged in the same way as non small cell lung cancer. Its two categories are limited stage or extensive stage.


Lung carcinoid is now more commonly diagnosed than in the past. Carcinoid is very different from non-small cell and small cell lung cancers. This tumor starts with different types of cells called neuroendocrine cells (cells that produce hormones). These cells line the small intestines as well as the lungs and can be typical or atypical. Many cancer centers have developed carcinoid programs to treat patients with this specific malignancy.


Malignant Mesothelioma is not the same as lung cancer. This cancer affects the lining of organs – this includes not only the lung, but also the abdomen and heart.
There are three main types of mesothelioma. The most common type is epithelioid. Other types are sarcomatoid and mixed/biphasic. Epithelioid mesothelioma grows slowly and often responds better to treatment than the other types.

Several factors make mesothelioma stand out from different types of cancer.

  • Mesothelioma is not directly linked with smoking. Although cigarette smoking can worsen mesothelioma symptoms, it is not the direct cause of the disease.
  • Mesothelioma is the only cancer linked with asbestos exposure. The exposure to asbestos may be direct (working in a shipyard or installing asbestos driveways) or indirect (washing the clothes of a spouse who worked in a plant or shipyard). Exposure may occur via inhalation (breathing in asbestos) or ingestion (swallowing asbestos fibers). Victims typically do not realize they are being exposed.
  • Mesothelioma is not found as a tumor in a certain part of the lung or abdomen. Instead, it is found in the lining of the lung (pleura), lining of the heart (pericardium), or lining of the abdomen (peritoneum).

Asbestos Related Lung Disease

While mesothelioma and lung cancer are two separate diseases, it is still possible to develop lung cancer after asbestos exposure. Many studies show an increased risk of lung cancer in workers exposed to asbestos. Those who have been exposed to asbestos and also smoke have a higher chance of lung cancer.

Asbestosis is another condition directly related to asbestos exposure. Over time, the lung tissue becomes scarred and can become lung cancer. Smoking compounds the risk of asbestosis becoming lung cancer.

Although both diseases have very similar symptoms, they are very different cancers in the way they are diagnosed and treated.

Page Edited by Dave Foster

Dave has been a mesothelioma Patient Advocate for over 10 years. He consistently attends all major national and international mesothelioma meetings. In doing so, he is able to stay on top of the latest treatments, clinical trials, and research results. He also personally meets with mesothelioma patients and their families and connects them with the best medical specialists and legal representatives available. Connect with Patient Advocate Dave Foster

Page Medically Reviewed and Edited by
Luis Argote-Greene, MD

Luis Marcelo Argote-Greene, MD
Luis Argote-Greene is an internationally recognized thoracic surgeon. He has trained and worked with some of the most prominently known thoracic surgeons in the United States and Mexico, including pioneering mesothelioma surgeon Dr. David Sugarbaker. He is professionally affiliated with University Hospitals (UH). His areas of interest and expertise are mesothelioma, mediastinal tumors, thoracic malignancies, lung cancer, lung transplantation, esophageal cancer, experimental surgery, and lung volume reduction. Dr. Argote-Greene has also done pioneering work with video-assisted thoracoscopic surgery (VATS), as well as robotic assisted minimally invasive surgery. He has taught the procedures to other surgeons both nationally and internationally.

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