Michele Carbone, MD, PhD
Dr. Michele Carbone is a world-renowned cancer researcher with special expertise in mesothelioma. He holds several positions and provides pathologic support at the University of Hawaii Cancer Center in Honolulu, Hawaii. Dr. Carbone specializes in exploring pleural mesothelioma and its causes. He is a board-certified pathologist and a strong proponent of a multidisciplinary collaborative team approach to both research and care.[1]
Education and Career
Dr. Carbone earned his medical degree and his PhD at the Medical School of Rome, “La Sapienza” in Italy. He is board-certified in Anatomic Pathology by both the University of Rome in Italy and the University of Chicago, where he maintained a research laboratory to continue investigations into the causes and potential cures for malignant mesothelioma.[1]
Dr. Carbone is currently the Director of Thoracic Oncology at the University of Hawaii Cancer Center. He is a professor and researcher at the University of Hawai’i Cancer Center and a professor in the Department of Pathology at the John A. Burns School of Medicine at the University of Hawai’i at Manoa.
Dr. Carbone is also a Full Member of the Cancer Biology Program, Special Health and Science Advisor to the Governor of Hawaii, and the William & Ellen Melohn Chair in Cancer Biology & Human Cancer Genetics.
Research
Dr. Carbone’s scientific research largely focuses on malignant mesothelioma. He explores the potential link between exposure to asbestos and genetics and has spent a significant amount of his time investigating an epidemic of malignant mesothelioma in the remote villages of Turkey.
His research has been instrumental in understanding mesothelioma and its causes. His work has included the discovery of the BAP1 gene mutation’s link to mesothelioma, finding more treatable genetic subgroups of mesothelioma patients, and groundbreaking work on the SV40 virus and its role in causing cancer.
He has several active grants, including:[1]
M. Carbone, Contact PI; H. Yang, Co-PI
NCI
1R01CA237235
“Mechanisms of BAP1 activity in human cancer development”
12/13/19–11/30/24
M. Carbone, Contact PI, H. Yang (U. Hawaiʻi), Grzymski, DRI, Nevada, Co-PIs
NIEHS
1R01ES030948
“Influence of germline mutations on susceptibility to environmental carcinogens”
08/15/19–06/30/24 (NCE)
M. Carbone, PI
UH Foundation through unrestricted donations from Honeywell Int. Inc., Riviera United-4-a Cure, Maurice and Joanna Sullivan Family Foundation
“Pathogenesis of Malignant Mesothelioma”
07/01/10–ongoing
His recent publications include:[1]
Suarez JS, Novelli F, Goto K, Ehara M, Steele M, Kim JH, Zolondick AA, Xue J, Xu R, Saito M, Pastorino S, Minaai M, Takanishi Y, Emi M, Pagano I, Wakeham A, Berger T, Pass HI, Gaudino G, Mak TW, Carbone M*, Yang H. HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma. (2023) Proc Natl Acad Sci U S A. 26;120(39):e2307999120. *co-corresponding author, doi: 10.1073/pnas.2307999120. Epub 2023 Sep 20. PMID: 37729199; PMCID: PMC10523480 Impact Factor: 11.1
Bononi A, Wang Q, Zolondick AA, Bai F, Steele-Tanji M, Suarez JS, Pastorino S, Sipes A, Signorato V, Ferro A, Novelli F, Kim J, Minaai M, Takinishi Y, Pellegrini L, Napolitano A, Xu R, Farrar C, Goparaju C, Bassi C, Negrini M, Pagano I, Sakamoto G, Gaudino G, Pass HI, Onuchic JN, Yang H, Carbone M. (2023). BAP1 is a novel regulator of HIF-1α. Proc Natl Acad Sci U S A. 120(4):e2217840120. doi:10.1073/pnas.2217840120. PubMed PMID: 36656861; PMC9942908. Impact Factor: 11.1
Carbone M, Pass HI, Ak G, Alexander HR Jr, Baas P, Baumann F, Blakely AM, Bueno R, Bzura A, Cardillo G, Churpek JE, Dianzani I, De Rienzo A, Emi M, Emri S, Felley-Bosco E, Fennell DA, Flores RM, Grosso F, Hayward NK, Hesdorffer M, Hoang CD, Johansson PA, Kindler HL, Kittaneh M, Krausz T, Mansfield A, Metintas M, Minaai M, Mutti L, Nielsen M, O’Byrne K, Opitz I, Pastorino S, Pentimalli F, de Perrot M, Pritchard A, Ripley RT, Robinson B, Rusch V, Taioli E, Takinishi Y, Tanji M, Tsao AS, Tuncer AM, Walpole S, Wolf A, Yang H, Yoshikawa Y, Zolondick A, Schrump DS, Hassan R. (2022). Medical and surgical care of patients with mesothelioma and their relatives carrying germline BAP1 mutations. J Thorac Oncol; 17:873-889, doi: 10.1016/j.jtho.2022.03.014. Impact Factor: 20.4.
