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Raphael Bueno, M.D.

Dr. Raphael Bueno is a thoracic surgeon and currently serves as Chief of the Division of Thoracic Surgery and Vice Chair of Surgery for Cancer and Translational Research at Brigham and Women’s Hospital in Boston. Dr. Bueno also recently replaced legendary mesothelioma specialist Dr. David Sugarbaker as director of the hospital’s International Mesothelioma Program. He is dedicated to maintaining Brigham and Women’s world-leading place in mesothelioma treatment and research. Dr. Bueno is also an educator, serving as a professor of surgery at Harvard Medical School.

Education and Early Career

Dr. Bueno earned an undergraduate degree in biochemistry from Harvard College. While attending Harvard, Dr. Bueno studied bacterial nitrogen regulation in a biology laboratory at the Massachusetts Institute of Technology. In 1985, he graduated from Harvard Medical School with a Health Sciences and Technology graduate degree. His thesis earned him the Henry A. Christian award.

After graduation, Dr. Bueno began surgical training, working as an intern at Brigham and Women’s Hospital. While completing surgical residency at the same hospital, he studied insulin-like growth factor through a research fellowship. Dr. Bueno then completed a cardiothoracic surgical residency at Massachusetts General Hospital. Finally, Dr. Bueno accepted a position at Brigham and Women’s to begin private surgical practice and a dedicated research laboratory.

Current Position

Dr. Bueno spent his career at Brigham and Women’s Hospital, working with Dr. Sugarbaker and learning about mesothelioma and other cancers. In 2014, he took over for Dr. Sugarbaker as the director of the International Mesothelioma Program. Dr. Bueno is also the Chief of Thoracic Surgery, the Vice Chair of Surgery for Cancer and Translational Research, and a professor of surgery at Harvard Medical School.

When Dr. Bueno took over for Dr Sugarbaker, he made a commitment to keep Brigham and Women’s Hospital a top destination for mesothelioma patients. He plans to continue the program’s tradition of collaboration, multidisciplinary treatment approaches, research, and advancement of treatment techniques for mesothelioma.

As part of his new leadership role, Dr. Bueno has proven his commitment to patients with mesothelioma. He exclusively devotes each Friday to working with patients diagnosed with this devastating disease. Members of the multidisciplinary team gather to discuss cases and devise solutions to help those struggling with mesothelioma.

Dr. Bueno’s Research

While leadership, patient care, and teaching have been a significant part of Dr. Bueno’s career, research has also played a major role. When presented with several options to start his career, Dr. Bueno chose Brigham and Women’s Hospital because of the Thoracic Surgery Tumor Bank established by Dr. Sugarbaker.

Some of his early research, which benefitted greatly from access the tumor bank, searched for genes expressed in mesothelioma cancer cells, but not in those of similar cancers. Diagnosing mesothelioma is challenging, and understanding genetic aspects of the disease can help make it more accurate. Dr. Bueno discovered a simple gene-ratio technique that could be used as a clinical test to differentiate between two similar cancers: mesothelioma and adenocarcinoma. He continues to work on diagnostic tests, refining it to make the biopsy less invasive. Other areas of research have included gender in mesothelioma, patient-focused care, and the underlying causes of mesothelioma.

Much of Dr. Bueno’s research is funded by the National Cancer Institute and involves clinical trials. He is currently working on a phase II clinical trial testing a neoadjuvant chemotherapy drug in patients whose mesothelioma tumors can be treated with surgery. The trial is examining biomarker responses in mesothelioma tumors. Other clinical trials include extrapleural pneumonectomy, video-assisted thoracic surgery, and analysis of non-small cell lung cancer tissue samples.

Dr. Bueno also collaborates with colleagues in the radiology department at Brigham and Women’s Hospital, as well as professionals at the University of Chicago, the University of Massachusetts, Boston, and the Harvard School of Public Health.

Professional Organizations, Achievements, and Honors

During his career, Dr. Bueno has been the member of a number of professional organizations and received many professional awards. One important achievement was taking a Brigham and Women’s Hospital team to Israel to lead the first minimally invasive esophagectomy performed in that country. This team also taught local surgeons how to perform this surgery. He was also the first surgeon to use image-guided video-assisted thoracic surgery, also known as iVATS, to treat a patient with lung cancer.

Dr. Bueno’s honors include being named one of America’s Top Doctors several years running. Boston Magazine also recognized Dr. Bueno as a top thoracic surgeon. He is a fellow of the American College of Surgeons and an active member in a number of other professional organizations.

As a leader in mesothelioma treatment and research, Dr. Bueno has made a huge impact on the lives of actual patients. His research is changing how patients are diagnosed and treated. His emphasis on innovating diagnosis and collaborative treatment continue to advance the cause of mesothelioma.

Page Edited by Dave Foster

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Dave has been a mesothelioma Patient Advocate for over 10 years. He consistently attends all major national and international mesothelioma meetings. In doing so, he is able to stay on top of the latest treatments, clinical trials, and research results. He also personally meets with mesothelioma patients and their families and connects them with the best medical specialists and legal representatives available. Connect with Patient Advocate Dave Foster

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