Charles B. Simone, MD
Dr. Charles B. Simone is a radiation oncologist and specialist in the use of proton and photon radiation therapy and photodynamic therapy at Memorial Sloan Kettering Cancer Center in New York City and the New York Proton Center, where he is Chief Medical Officer. Dr. Simone treats patients with malignant pleural mesothelioma, lung cancer, and other thoracic malignancies.[1]
Education and Career
Dr. Simone completed his undergraduate and medical school training at the University of Pennsylvania and then completed an internship in Internal Medicine as well as residency training in Radiation Oncology at the National Cancer Institute, National Institutes of Health, where he served as chief resident.[1]
Before joining Memorial Sloan Kettering and the New York Proton Center, Dr. Simone was an Associate Professor of Radiation Oncology and Chief of Thoracic Oncology at the Hospital of the University of Pennsylvania, Director of the Penn Mesothelioma and Pleural Program for the University of Pennsylvania Health System, Medical Director for the Maryland Proton Treatment Center and an Associate Professor of Radiation Oncology at the University of Maryland School of Medicine.[1]
Professional Activities and Memberships
Dr. Simone is active in numerous professional and scientific organizations. He is the Chair of the Proton Collaborative Group (PCG) Lung Committee and the Chair of the American Society for Photobiology (ASP) Education Committee. He was appointed to the NRG Oncology (formerly Radiation Therapy Oncology Group [RTOG]) Lung Cancer Core Committee; NRG Radiation Oncology Committee; NCI Thoracic Malignancies Steering Committee Mesothelioma Working Group; International Thymic Malignancy Interest Group (ITMIG) Research and Infrastructure Committee; ITMIG Thymic Carcinoma Workgroup; American Society for Radiation Oncology (ASTRO) Lung Cancer “Blue Ribbon” Panel; PCG Reirradiation Committee; Particle Therapy Co-Operative Group (PTCOG) Scientific Committee; and multiple PTCOG Clinical Subcommittees.[3]
Research
In addition to his role as Chief Medical Officer of the New York Proton Center, Dr. Simone is also a research professor and internationally recognized expert in the use of proton therapy to treat thoracic malignancies and for reirradiation, and in developing innovative clinical trials in thoracic oncology and in stereotactic body radiation therapy using both proton and conventional photon therapies.[2]
Clinical Trials Investigated by Dr. Simone:[2]
- A Phase II Study of Durvalumab Immunotherapy and Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer
- A Phase III Study Assessing the Addition of Atezolizumab Immunotherapy to the Usual Radiation Treatment for Patients with Early Non-Small Cell Lung Cancer
Clinical Trials Co-Investigated by Dr. Simone[2]
His recent publications include:[footnote num=”2″}
Management of Stage III Non-Small-Cell Lung Cancer: ASCO Guideline.
Daly ME, Singh N, Ismaila N, Antonoff MB, Arenberg DA, Bradley J, David E, Detterbeck F, Früh M, Gubens MA, Moore AC, Padda SK, Patel JD, Phillips T, Qin A, Robinson C, Simone CB 2nd. J Clin Oncol. 2022 Apr 20;40(12):1356-1384. doi: 10.1200/JCO.21.02528. Epub 2021 Dec 22.PMID: 34936470 Review.
Roden AC, Ahmad U, Cardillo G, Girard N, Jain D, Marom EM, Marx A, Moreira AL, Nicholson AG, Rajan A, Shepherd AF, Simone CB 2nd, Strange CD, Szolkowska M, Truong MT, Rimner A.J Thorac Oncol. 2022 May;17(5):637-650. doi: 10.1016/j.jtho.2022.01.021. Epub 2022 Feb 25.PMID: 35227908 Free article. Review.
A phase 2 study of thalidomide for the treatment of radiation-induced blood-brain barrier injury.
Cheng J, Jiang J, He B, Lin WJ, Li Y, Duan J, Li H, Huang X, Cai J, Xie J, Zhang Z, Yang Y, Xu Y, Hu X, Wu M, Zhuo X, Liu Q, Shi Z, Yu P, Rong X, Ye X, Saw PE, Wu LJ, Simone CB 2nd, Chua MLK, Mai HQ, Tang Y.Sci Transl Med. 2023 Feb 22;15(684):eabm6543. doi: 10.1126/scitranslmed.abm6543. Epub 2023 Feb 22.PMID: 36812346 Clinical Trial.
Mascia AE, Daugherty EC, Zhang Y, Lee E, Xiao Z, Sertorio M, Woo J, Backus LR, McDonald JM, McCann C, Russell K, Levine L, Sharma RA, Khuntia D, Bradley JD, Simone CB 2nd, Perentesis JP, Breneman JC.JAMA Oncol. 2023 Jan 1;9(1):62-69. doi: 10.1001/jamaoncol.2022.5843.PMID: 36273324
Radiation Therapy for Small Cell Lung Cancer: An ASTRO Clinical Practice Guideline.
Simone CB 2nd, Bogart JA, Cabrera AR, Daly ME, DeNunzio NJ, Detterbeck F, Faivre-Finn C, Gatschet N, Gore E, Jabbour SK, Kruser TJ, Schneider BJ, Slotman B, Turrisi A, Wu AJ, Zeng J, Rosenzweig KE.Pract Radiat Oncol. 2020 May-Jun;10(3):158-173. doi: 10.1016/j.prro.2020.02.009. Epub 2020 Mar 23.PMID: 32222430
