Sean Dineen, MD
Dr. Sean Dineen is an Assistant Member of Moffitt Cancer Center’s Department of Gastrointestinal Oncology. His particular interest is in surgery for cancer patients whose disease has metastasized to the gastrointestinal or peritoneal region, including malignant pleural mesothelioma. He is particularly skilled in the highly effective procedure known as CRS/HIPEC, or cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.[1]
What is CRS/HIPEC?
CRS/HIPEC, or cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, is a procedure that combines surgery to remove all visible malignant cells from the abdominal region followed by a heated bath of chemotherapy. It has proven extremely effective in the treatment of malignant peritoneal mesothelioma, as the highly concentrated chemotherapy solution is delivered directly to the site where any remaining cancer cells may be, impacting them directly rather than systemically. This means fewer side effects, better outcomes, and improved quality of life for patients.[2]
Surgeons who perform CRS/HIPEC must be highly experienced in the procedure, and there are only a few cancer centers throughout the country where it is available. Dr. Dineen is part of Moffitt Cancer Center’s multidisciplinary team that assesses peritoneal mesothelioma patients’ needs to determine whether they are eligible for this protocol.
Education and Career
Dr. Dineen earned his medical degree at the University of Louisville, then completed his residency in General Surgery at UT Southwestern in Dallas. His program extended into a research fellowship focused on the tumor microenvironment. His interest in the topic extended into his fellowship in Complex General Surgical Oncology at MD Anderson Comprehensive Cancer Center, where he was recognized for Clinical Excellence by the Department of Surgery.[1]
After completing his education, Dr. Dineen went on to become the Medical Director of the Multidisciplinary Clinic at Markey Cancer Center at the University of Kentucky. He is now an Assistant Member of the Department of Gastrointestinal Oncology at Moffitt Cancer Center.
Research
Dr. Dineen’s research interest lies in the tumor and its local environment, and the exploration of how the two interact to promote cancer cells metastasizing to other parts of the body. He has published numerous articles on the topic and presented both nationally and internationally on the topic of both gastrointestinal and peritoneal cancers and other diseases.
Professional Memberships
Dr. Dineen is a member of the American College of Surgeons (ACS), the Americas Hepato-Pancreato-Biliary Association (AHPBA), and the Society for Surgeons of the Alimentary Tract (SSAT).[1]
